The Global Matrine Market was valued at USD 44 million in 2023 and is projected to reach USD 55.92 million by 2032, growing at a Compound Annual Growth Rate (CAGR) of 2.70% during the forecast period (2024–2032). This expansion reflects rising demand for natural alkaloid compounds across healthcare and organic agriculture sectors, driven by increasing regulatory restrictions on synthetic chemicals.

As pharmaceutical researchers rediscover traditional plant-based remedies and farmers adopt sustainable pest control solutions, matrine’s dual applications in medicine and agriculture are creating new market opportunities. Below we analyze the Top 10 Matrine Producers—from specialized biotech firms to vertically integrated manufacturers—that are defining quality standards in this evolving sector.

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🔟 1. Lisi (Xian) Bio-Tech

Headquarters: Xi’an, China
Key Offering: 98% Pharmaceutical-Grade Matrine

This GMP-certified manufacturer controls 18% of China’s matrine production capacity through advanced Sophora flavescens extraction processes. Their dual focus on domestic pharmaceutical contracts and international exports positions them as a key supplier to formulation companies worldwide.

Technical Advantages:

• Patent-pended low-temperature extraction method preserves alkaloid integrity
• ISO 13485 certified quality management for medical applications
• Specializes in matrine hydrochloride for injectable formulations

Download FREE Sample Report: Matrine Market – View in Detailed Research Report

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9️⃣ 2. Xi’an Lyphar Biotech

Headquarters: Xi’an, China
Key Offering: Research-Grade Matrine Standards

Lyphar serves academic and pharmaceutical research institutions with analytical reference standards and bulk matrine certified to USP/EP monographs. Their product documentation includes full chromatographic profiles and stability data critical for drug development.

Research Focus:

• Supplies 28 global pharmaceutical research centers
• Maintains batch-to-batch consistency within ±2% purity variance

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8️⃣ 3. Shenzhen Horizon Industry

Headquarters: Shenzhen, China
Key Offering: Matrine-Based Organic Pesticides

Horizon’s agricultural division developed China’s first OMRI-listed matrine insecticide, capturing 22% of the domestic biopesticide market. Their formulations combine matrine with botanical synergists to enhance pest control efficacy.

Agricultural Solutions:

• EPA and EU organic certifications for 14 crop protection products
• Field-proven 85-92% efficacy against common agricultural pests

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7️⃣ 4. Shaanxi Herbchem Biotech

Headquarters: Xi’an, China
Key Offering: Industrial-Scale Matrine Production

With 300-ton annual capacity, Herbchem supplies bulk matrine to Fortune 500 pharmaceutical companies. Their competitive edge comes from proprietary wastewater treatment systems that reduce production costs by 18% compared to industry averages.

Manufacturing Prowess:

• Closed-loop extraction process minimizes solvent use
• Automated quality control reduces human error in purity testing

Download FREE Sample Report: Matrine Market – View in Detailed Research Report

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6️⃣ 5. Xi’an Tian Guangyuan Biotech

Headquarters: Xi’an, China
Key Offering: Ultra-Pure Matrine for Drug Formulation

Tian Guangyuan’s 99.7% purity matrine meets ICH Q3D elemental impurity guidelines, making it suitable for parenteral drug products. The company invests 12% of revenues in novel drug delivery system research.

Pharmaceutical Expertise:

• Supplies 8 of the top 10 Chinese traditional medicine manufacturers
• Proprietary nanoliposome encapsulation technology enhances bioavailability

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5️⃣ 6. Xi’an Realin Biotechnology

Headquarters: Xi’an, China
Key Offering: Standardized Sophora Extracts

Realin differentiates through whole-plant extraction protocols that preserve matrine’s natural co-factors. Their products appeal to functional food and nutraceutical manufacturers seeking clinically validated botanical ingredients.

Holistic Approach:

• 30+ bioactive markers quantified per batch
• Clinical trial materials for 6 matrine-based supplement studies

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4️⃣ 7. Xi’an Huisun Bio-Tech

Headquarters: Xi’an, China
Key Offering: Veterinary Matrine Formulations

Specializing in animal health, Huisun developed the first matrine-based acaricide approved for livestock by China’s Ministry of Agriculture. Their products show 97% efficacy against ectoparasites without antibiotic residues.

Animal Health Focus:

• GMP+ certified production for feed additives
• Patented slow-release technology extends antiparasitic action

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3️⃣ 8. Baoji Herbest Bio-Tech

Headquarters: Baoji, China
Key Offering: Certified Organic Matrine

Herbest’s USDA/NOP and EU organic certified extracts command premium pricing in Western markets. Their traceable supply chain tracks matrine from wild-harvested Sophora to finished products.

Sustainability Credentials:

• FairWild certified wild harvesting practices
• Carbon-neutral production through renewable energy use

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2️⃣ 9. NutraGreen Biotechnology

Headquarters: Nanjing, China
Key Offering: GRAS-Certified Matrine Ingredients

NutraGreen expanded matrine’s applications through self-affirmed GRAS status in the U.S., enabling use in dietary supplements. Their trademarked Matriplex® technology improves solubility and absorption.

Regulatory Achievements:

• Dossier submissions to FDA for 3 matrine-containing supplements
• Successful Novel Food authorization in the EU

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1️⃣ 10. Kingherbs Limited

Headquarters: Hong Kong
Key Offering: Global Matrine Distribution

As a regulatory specialist, Kingherbs bridges Asian producers with international buyers by handling complex import/export documentation for pharmaceutical and agricultural applications.

Supply Chain Solutions:

• Maintains warehouses in 7 countries for just-in-time delivery
• Provides Certificate of Suitability (CEP) support for European markets

Get Full Report Here: Matrine Market – View in Detailed Research Report

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🌱 Market Outlook: Matrine’s Expanding Applications

The matrine industry stands at an inflection point as clinical validations and agricultural efficacy studies reveal new potential for this versatile alkaloid. With China dominating production but global demand rising, strategic partnerships are reshaping supply chains.

📈 Emerging Industry Developments:

• Phase II trials investigating matrine’s anti-fibrotic effects in pulmonary diseases
• Combination products with synthetic pesticides reducing chemical usage by 40-60%
• Blockchain implementations improving supply chain transparency from farm to formulation
• U.S. EPA fast-tracking reviews of matrine-based biopesticides

Get Full Report Here: Matrine Market – View in Detailed Research Report

These innovation leaders are transforming matrine from a niche botanical extract into a multi-industry solution with validated scientific applications.