The Global Polymer Based Solubility Enhancement Excipients Market was valued at USD 2.82 Billion in 2023 and is projected to reach USD 6.67 Billion by 2030, growing at a Compound Annual Growth Rate (CAGR) of 13.1% during the forecast period (2024-2030). This growth is driven by increasing pharmaceutical R&D investments, the prevalence of poorly soluble drug candidates, and advancements in drug delivery technologies.

With approximately 40% of marketed drugs and 90% of pipeline candidates facing solubility challenges, polymer-based excipients have become essential formulation components. These specialized materials improve drug bioavailability through advanced technologies like solid dispersions and particle engineering. Here we analyze the Top 10 Companies in the Polymer Based Solubility Enhancement Excipients Market—industry leaders developing innovative solutions for pharmaceutical formulations.

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🔟 1. Ashland Global Holdings Inc.

Headquarters: Wilmington, Delaware, USA
Key Products: Klucel™ HPC, Benecel™ HPMC, AquaKeep™ polymers

Ashland is a pioneer in cellulose-based excipients, offering comprehensive solutions for solubility enhancement through controlled release technologies and bioavailability improvement. Their polymer portfolio serves hot-melt extrusion and spray drying applications.

Technology Advantages:

• Industry-leading hydroxypropyl cellulose formulations
• Specialized excipients for amorphous solid dispersions
• GMP-certified global manufacturing network

Download FREE Sample Report: Polymer Based Solubility Enhancement Excipients Market – View in Detailed Research Report

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9️⃣ 2. BASF SE

Headquarters: Ludwigshafen, Germany
Key Products: Kollicoat®, Soluplus®, EUDRAGIT® polymers

BASF provides one of the most comprehensive solubility enhancement portfolios, including the pioneering Soluplus® graft copolymer specifically engineered for poorly soluble drugs.

Technology Advantages:

• Patented amorphous solid dispersion technology
• Multi-functional co-processed excipient systems
• Global technical support for formulation development

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8️⃣ 3. Dow Chemical Company

Headquarters: Midland, Michigan, USA
Key Products: METHOCEL™, ETHOCEL™, AFFINISOL™ HPMC HME

Dow’s cellulose ether products enable solubility enhancement through particle size reduction and solid dispersion techniques, with specialized polymers for hot-melt extrusion processing.

Technology Advantages:

• Optimized molecular weight distributions for solubility
• Formulation expertise across multiple drug delivery systems
• Global quality and regulatory compliance

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7️⃣ 4. Evonik Industries AG

Headquarters: Essen, Germany
Key Products: EUDRAGIT®, RESOMER®, SOLUPLUS® polymers

Evonik offers functional polymer solutions that enhance drug solubility through multiple mechanisms, serving oral, injectable, and implantable drug delivery applications.

Technology Advantages:

• Co-processing technologies for superior performance
• Tailored excipient solutions for bioavailability enhancement
• End-to-end formulation development support

Download FREE Sample Report: Polymer Based Solubility Enhancement Excipients Market – View in Detailed Research Report

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6️⃣ 5. Shin-Etsu Chemical Co., Ltd.

Headquarters: Tokyo, Japan
Key Products: Metolose®, Pharmacoat®, Ceolus™

Shin-Etsu dominates the Asian market for methylcellulose and HPMC excipients, offering high-purity polymers for solubility enhancement applications.

Technology Advantages:

• Specialty grades for spray drying applications
• Strict quality control with global GMP compliance
• Technical expertise in Asian pharmaceutical markets

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5️⃣ 6. Clariant AG

Headquarters: Muttenz, Switzerland
Key Products: Parteck®, VitiPure®, SoluMatrix®

Clariant provides innovative solutions like Parteck® SLC for solubility enhancement of poorly soluble APIs through advanced particle engineering technologies.

Technology Advantages:

• SoluMatrix® particle size reduction technology
• Multifunctional excipient combinations
• Solutions for fast-dissolving formulations

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4️⃣ 7. The Lubrizol Corporation

Headquarters: Wickliffe, Ohio, USA
Key Products: Carbopol®, Noveon®, Pemulen®

Lubrizol specializes in acrylic acid polymer solutions that address solubility challenges through pH-dependent mechanisms and bioadhesive properties.

Technology Advantages:

• Customized polymer solutions for challenging APIs
• Specialized excipients for enhanced absorption
• Formulation expertise across dosage forms

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3️⃣ 8. Roquette Frères

Headquarters: Lestrem, France
Key Products: Kleptose®, Lycoat®, Pearlitol®

Roquette offers plant-based polymer solutions including cyclodextrins for complexation-based solubility enhancement of poorly soluble drugs.

Technology Advantages:

• Natural source excipients with excellent safety profiles
• Sustainable manufacturing processes
• Global regulatory support and documentation

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2️⃣ 9. SPI Pharma

Headquarters: Wilmington, Delaware, USA
Key Products: AcDiSol®, Vivastar®, Microcel®

SPI Pharma provides specialized superdisintegrants and particle-engineered excipients that enhance drug solubility in immediate-release formulations.

Technology Advantages:

• Croscarmellose sodium-based technologies
• Functional co-processed excipient systems
• Solutions for fast-dissolving dosage forms

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1️⃣ 10. Colorcon Inc.

Headquarters: Harleysville, Pennsylvania, USA
Key Products: Opadry®, Optisolve®, Acryl-EZE®

Colorcon develops multi-functional polymer systems that combine solubility enhancement with other critical formulation properties in ready-to-use solutions.

Technology Advantages:

• Integrated formulation solutions
• Co-processed polymer combinations
• Global technical service network

Get Full Report Here: Polymer Based Solubility Enhancement Excipients Market – View in Detailed Research Report

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🔬 Market Outlook: Advancing Pharmaceutical Formulation Science

The polymer based solubility enhancement excipients market is undergoing significant transformation as pharmaceutical companies demand more sophisticated solutions to address bioavailability challenges in drug development.

📈 Key Market Dynamics:

• Accelerating adoption of amorphous solid dispersion technologies
• Development of multi-functional excipient combinations
• Expansion of hot-melt extrusion and spray drying capabilities
• Growing focus on pediatric and geriatric-friendly formulations
• Regulatory emphasis on demonstrating bioequivalence

Get Full Report Here: Polymer Based Solubility Enhancement Excipients Market – View in Detailed Research Report

The companies profiled above are driving pharmaceutical innovation by developing advanced excipient technologies that solve critical formulation challenges while meeting evolving regulatory requirements.